• Users Online: 113
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2018  |  Volume : 15  |  Issue : 1  |  Page : 48-52

Immune profile in aborted Iraqi women with toxoplasmosis


1 Medical Research Unit, College of Medicine, Al-Nahrain University, Baghdad, Iraq
2 Medical Technical Institute, Baghdad, Middle Technical University, Baghdad, Iraq
3 Department of Pathology, College of Medicine, Al-Nahrain University, Baghdad, Iraq
4 Department of Medical Microbiology, College of Medicine, Al-Nahrain University, Baghdad, Iraq
5 Department of Biology, College of Science, Baghdad University, Baghdad, Iraq

Correspondence Address:
Muhammed Abdul-Gabar Hamoodi Aldabagh
Medical Research Unit, College of Medicine, Al-Nahrain University, Baghdad
Iraq
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/MJBL.MJBL_13_18

Get Permissions

Background: Toxoplasmosis is one of the most important causes for abortion in women. The immune responses have a role in the outcome of such infection in gestated women. Aim: The current study was designed to investigate the immune profile in aborted Iraqi women with toxoplasmosis. Materials and Methods: Fifty-five aborted women and 29 healthy control women were enrolled in this study. Enzyme-linked immunosorbent assays were used to estimate serum levels to each of interleukin-1 alpha (IL-1α), granulocyte-monocyte colony-stimulating factor, IL-8, IL-4 IL-10, IL-12, interferon gamma (INF-γ), and IL-6. Single-radial-immunodiffusion assay was used to estimate serum levels of C3, C4, and total immunoglobulin gamma. Results: Serum levels of IL-8 showed significant elevation, while IL-6 and INF-γ showed significant dropping in infected women compared to control. Other immune factors showed nonsignificant differences between the two groups of the present study. Conclusion: Disturbance of immune response associated with toxoplasmosis may explain the success of parasite in escaping from discrimination and elimination by the immune system then supporting its survival and replication.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1114    
    Printed89    
    Emailed1    
    PDF Downloaded129    
    Comments [Add]    

Recommend this journal