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ORIGINAL ARTICLE
Year : 2018  |  Volume : 15  |  Issue : 4  |  Page : 376-380

Role of hepcidin in hearing loss


1 Department of Physiology, College of Medicine, Kufa University, Najaf, Iraq
2 Department of Surgery, College of Medicine, Kufa University, Najaf, Iraq
3 Department of Pharmacology, College of Pharmacy, Kufa University, Najaf, Iraq

Correspondence Address:
Rawaa H Shareef
Department of Pharmacology, College of Pharmacy, Kufa University, Najaf
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/MJBL.MJBL_106_18

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Background: Hearing loss is considered as a public health problem that affects the population at all ages.Hepcidin is an important protein with a crucial role in the homeostasis and metabolism of iron. Objective: The objective of this study was to evaluate the association between hepcidin and hearing loss and to find out the mechanisms that lead to this association. Materials and Methods: A total of 300 persons included in this study, 150 as a patients' group who are suffering from hearing loss and attended Al-Sadder Teaching Hospital in Al-Najaf Al-Ashraf City, Iraq, while the other 150 participants who are selected randomly as controls' group and are free from hearing loss. The ages of all participants ranged between 18 and 70years, and controls were matched with patients by gender and age(within 5years). Many parameters are measured such as hepcidin, C-reactive protein(CRP), interleukin-6(IL-6), advanced glycation end products(AGEs), and glutathione peroxidase-3(GPX-3). Results: The results of this study revealed that sensorineural hearing loss was the most common type followed by mixed one. Furthermore, it was shown that hepcidin and CRP were significantly higher in patients compared with controls, while there were no significant differences between patients and controls in the levels of IL-6, AGEs, and GPX-3. The correlation analyses showed a significant positive correlation between hepcidin and CRP and hepcidin and IL-6. Conclusion: Hepcidin and CRP have a negative impact on hearing, increase significantly with hearing loss, and have role in the development of hearing loss.


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