• Users Online: 477
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2019  |  Volume : 16  |  Issue : 1  |  Page : 31-35

Evaluation of serum level of soluble lectin-like oxidized low-density lipoprotein receptor-1 and its relationship with severity of preeclampsia and birth weight


1 Department of Biochemistry, College of Pharmacy, Uruk University, Baghdad, Iraq
2 Department of Chemistry, College of Medicine, Al-Nahrain University, Baghdad, Iraq
3 Department of Gynecology and Obstetrics, College of Medicine, Al-Nahrain University, Baghdad, Iraq

Correspondence Address:
Dr. Hiba Ghassan Rajab
College of Pharmacy, Uruk University, Baghdad
Iraq
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/MJBL.MJBL_121_18

Get Permissions

Background: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is one of the pattern recognition receptors that plays a critical role in vascular diseases and host immune response, LOX-1 can induce endothelial dysfunction through pathways implicated with oxidative stress and inflammation that ends with vascular lesions. Objective: The objective of the study is to evaluate the serum level of soluble LOX-1 (sLOX-1) in preeclampsia (PE) and normal pregnancy to study its relationship with the severity of PE and birth weight. Materials and Methods: A total of 56 patients with PE were allocated to the study together with 28 healthy pregnant women as normal controls. PE patients divided into 28 mild and 28 severe PE. Levels of serum sLOX-1 were measured by sandwich enzyme-linked immunosorbent assay technique. Results: Results showed a significant increase in the serum sLOX-1 in preeclamptic patients (P < 0.01) compared to normal controls. The significance increased in serum levels of sLOX-1, was noted in mild (P = 0.001) and severe patients (P = 0.001), compared to normal controls. There was a significant decrease in fetal birth weight in severe PE as compared to mild and control groups which was correlated with sLOX-1, furthermore, logistic regression of the variables for the presence of low birth weight <2.5 kg. Conclusion: High level of serum sLOX-1 is associated with the occurrence and severity of PE, which provides additional information for predicting of PE and preventing its complications and for better understanding pathogenesis of PE and the results highlight the involvement of innate immunity molecules and inflammation in pathogenesis of PE through binding to apoptotic cells and angiogenic process.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed492    
    Printed72    
    Emailed1    
    PDF Downloaded78    
    Comments [Add]    

Recommend this journal