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ORIGINAL ARTICLE
Year : 2019  |  Volume : 16  |  Issue : 2  |  Page : 136-140

Serum protein levels and albumin/globulin ratio in patients with uterus, ovary, and breast tumors compared to healthy women in Kirkuk City


1 Department of Chemistry, College of Science, Kirkuk University, Kirkuk, Iraq
2 Department of Gynecology and Obstetrics, Azadi Teaching Hospital, Kirkuk, Iraq

Correspondence Address:
Israa Ghassan Zainal
Department of Chemistry, College of Science, Kirkuk University, Kirkuk
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/MJBL.MJBL_10_19

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Background: Gynecological cancer is one of the most serious public health problems in the world with main gynecological cancers, uterus, breast, and ovarian, causing morbidity with severe suffering and a high mortality. Objective: This study aimed to investigate the levels of the total protein (TP), albumin (Alb), globulin (Glo), and Alb/Glo ratio in the female patients with (uterus, ovary, and breast) cancer compared to healthy females. Materials and Methods: This study included 120 females with (28 uteri, 31 ovaries, and 25 breasts) cancer patients and 36 healthy control participants, with age ranges between (20 and 42) years. Results: Alb levels significantly (P ≤ 0.05) decreased in all patient samples except those with uterus cancer who showed significant increase (P ≤ 0.05) compared to healthy participants, and Glo levels significantly (P ≤ 0.05) decreased for uterus and breast cancer samples and nonsignificant (P ≤ 0.05) decrease in patients with ovary cancer compared to healthy participants; finally, the ratio of Alb./Glo. showed significant (P ≤ 0.05) decrease in all patients group except patients with breast cancer showed significant increase (P ≤ 0.05) compared to healthy participants. The results of correlation coefficient indicated that there were significant (P ≤ 0.05) positive correlations between TP and Glo for uterus and breast cancer patients and between TP and Alb for ovary cancer patients. Conclusion: The ratio of Alb/Glo was significantly (P ≤ 0.05) decreased in all patients group except patients with breast cancer who showed significant increase (P ≤ 0.05) compared to healthy participants which could be used in the diagnosis of these patients.


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