• Users Online: 424
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2019  |  Volume : 16  |  Issue : 2  |  Page : 89-93

Interaction of sodium dodecyl sulfate with anticancer drug 6-mercaptopurine


1 Department of Pharmaceutics, Faculty of Pharmacy, Kufa University, Najaf, Iraq
2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kufa University, Najaf, Iraq
3 Department of Chemistry, Faculty of Science, Kufa University, Najaf, Iraq

Correspondence Address:
Alaa A Habeeb
Department of Pharmaceutics, Faculty of Pharmacy, Kufa University, Najaf
Iraq
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/MJBL.MJBL_3_19

Get Permissions

Background: 6-Mercaptopurine (6-MP) is used in the conventional chemotherapy of patients with acute lymphoblastic leukemia. Materials and Methods: Sodium dodecyl sulfate (SDS), an anionic surfactant that is commonly used to mimic hydrophobic binding environments such as cell membranes, micellization behavior of sodium dodecyl sulfate (anionic surfactant) has been studied in the presence of 6-MP (anticancer drug) at (1 × 10−5 M) concentrations with different time periods in micelle solution, studied at 37°C. Results: The results showed increase the absorbance values for the pharmaceutical compound (6-MP). Increase the absorbance values of pharmaceutical compounds with 1 × 10−2 critical micelle concentration values of surfactant increase of 6-MP concentrations in micelle solution, with decrease its concentrations in organic media, various thermo-dynamic parameters such as standard-free energy of micellization ΔG (0.6216 k J.mol−1), that have direct bearing on the consequences of such interactions at the molecular level have been calculated. Depend on Keq and slope values for reversible reactions. Conclusion: The above-calculated parameters were found to be sensitive toward the interactions prevailing in 6-MP–SDS–hexane-water systems. After fixed the experimental optimum conditions at pH 7.4, 37°C, and λmax 322 nm.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed259    
    Printed41    
    Emailed0    
    PDF Downloaded54    
    Comments [Add]    

Recommend this journal