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ORIGINAL ARTICLE
Year : 2019  |  Volume : 16  |  Issue : 3  |  Page : 184-187

Hematological parameters in children with type-1 diabetes


1 Department of Pediatrics, Raparin Pediatric Hospital, Erbil, Iraq
2 Department of Pediatrics, College of Medicine, Hawler Medical University, Erbil, Iraq

Correspondence Address:
Kamal Hussein Khudhur
Department of Pediatrics, Raparin Pediatric Hospital, Erbil
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/MJBL.MJBL_24_19

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Background and Objective: This study was done to investigate and compare the hematological parameters related to hemoglobin (Hb), total white blood cell (WBC) count, and platelet parameters in a case–control study of patients with diabetes with those of nondiabetic healthy persons, potentially predisposing patients with diabetes to complications. Materials and Methods: A case–control study consisted of 50 children with type I diabetes have been diagnosed since 5 years attending Laila Qasim Diabetic Center compared with another 50 nondiabetic healthy children attending Pediatric Clinic at Raparin Pediatric Hospital from October 2018 to March 2019. Investigations were done as follows: (a) both patients and controls including Hb (g/dl), total WBC count (109/L), platelet count (109/L), mean platelet volume (MPV) (fl), platelet distribution width (PDW) (fl), platelet-large cell ratio (P-LCR) (%), and (b) patients only HbA1C (%) to know their control state. Results: WBC, MPV, PDW, and P-LCR were significantly higher among children with diabetes in comparison with the control group (WBC 9.34 ± 1.56 109/L vs. 8.14 ± 1.88 109/L, P = 0.001; MPV 9.60 ± 1.13 fL vs. 8.07 ± 0.87 fL, P = 0.001; PDW 11.91 ± 1.18 fL vs. 10.03 ± 1.1 fL, P = 0.001; and P-LCR 19.34% ± 4.85% vs. 12.09% ± 4.37%, P = 0.001); Hb was significantly lower among children with diabetes in comparison with the control group (Hb 12.61 ± 0.75 g/dl vs. 12.89 ± 0.64 g/dl, P = 0.04); No significant difference was detected between the two groups regarding platelet count. Conclusion: The study revealed that hematological parameters changed as a result of diabetes mellitus, especially Hb was decreased among patients with diabetes and WBC, MPV, PDW, and P-LCR were highly elevated in type I as compared with nondiabetic participants.


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