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ORIGINAL ARTICLE
Year : 2019  |  Volume : 16  |  Issue : 3  |  Page : 224-228

Rituximab for the treatment of pemphigus and pemphigoid: A case series of ten patients


1 Department of Dermatology, Mergan Teaching Hospital, Babylon Health Directorate, Babylon, Iraq
2 Department of Public Health, Mergan Teaching Hospital, Babylon Health Directorate, Babylon, Iraq

Correspondence Address:
Khalid H Al-Shibly
Department of Public Health, Mergan Teaching Hospital, Babylon Health Directorate, Babylon
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/MJBL.MJBL_25_19

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Background: Autoimmune bullous skin disorders are rare but potentially fatal disorders of the skin and mucous membranes. These diseases may require long-term treatment with systemic corticosteroids and other immunosuppressive drugs, which can lead to serious adverse events. Rituximab has proved to be effective form of therapy for pemphigus and pemphigoid. Objective: The aim of this study was to evaluate the effectiveness of a full coarse treatment with rituximab for cases of pemphigus and pemphigoid. Materials and Methods: A case series study involved ten cases of pemphigus and pemphigoid consulted the Dermatology Department of Merjan Teaching Hospital, Babylon, and treated with a full course of rituximab. Results: A complete remission (CR) has been achieved in the vast majority of cases, whereas the side effects were trivial and rare. Conclusions: Rituximab has proved to be effective form of therapy for pemphigus. A CR has been achieved in the vast majority of cases, whereas the side effects were trivial and rare.


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