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Year : 2019  |  Volume : 16  |  Issue : 3  |  Page : 243-247

Rubella virus seroprevalence and associated factors in pregnant women with and without previous spontaneous abortion

1 Department of Gynecology, Abu-Grabe Hospital, Baghdad, Iraq
2 Department of Pathology, Ministry of Agriculture, Baghdad, Iraq

Correspondence Address:
Raghad Adel Mohammed
Department of Gynecology, Abu-Grabe Hospital, Baghdad
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/MJBL.MJBL_43_19

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Background: Rubella virus infection is associate with various pregnancy outcomes. Usually, such infection is more prevalent among women with low positivity for protective immunoglobulin G (IgG). Several factors are known to influence the seroprevalence of this virus. Objectives: This study aimed to investigate the seroprevalence of anti-rubella IgG and immunoglobulin M (IgM) antibodies and associated factors among pregnant women with and without a history of abortion. Materials and Methods: A total of 91 pregnant women (79 women with a history of previous abortion and 12 women without such history) were enrolled in this cross-sectional study. Sera were collected from each woman, and the levels of rubella IgG and IgM were measured using enzyme-linked immunosorbent assay. Demographic and reproductive data for the women were also collected. Univariate logistic regression was used to find the association of factor with serostatus of the virus. Results: The overall seropositivity for IgG and IgM was 95.6%, (95% confidence interval [CI] = 91.3–99.9) 9.89%, (95% CI = 9.68–10.1), while six women (6.59%) were positive for both types of Igs. Two factors showed a significant association with rubella IgG seropositivity: A history of previous abortion (odds ratio [OR] = 0.68, 95% CI =, P < 0.001). Moreover, urban residence (OR = 1.09, 95% CI = 1.0–1.19, P = 0.048). On the other hand, younger age (≤28 years) (OR = 0.1, 95% CI = 0.01–0.82) and previous abortion (OR = 0.14, 95% CI = 0.03–0.61) were significantly associated with IgM positivity. Conclusions: Most women are protected from rubella virus infection through possessing a high level of IgG; however, there is a considerable proportion with evidence of acute infection which indicate that the virus is endemic in the study area.

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