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ORIGINAL ARTICLE
Year : 2020  |  Volume : 17  |  Issue : 1  |  Page : 54-57

Association of catechol-O-methyltransferase gene polymorphism with benign prostatic hyperplasia in Babylon Province


1 Department of Biochemistry, College of Medicine, University of Babylon, Babylon Province, Iraq
2 Department of Surgery, College of Medicine, University of Babylon, Babylon Province, Iraq

Correspondence Address:
Dr. Nibras Yahya Hussein
Department of Biochemistry, College of Medicine, University of Babylon, Babylon Province
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/MJBL.MJBL_83_19

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Background: Benign prostatic hyperplasia (BPH) is a common nonmalignant disorder in elderly men. Objectives: The objective of the present study was planned to evaluate the frequency and association of catechol-O-methyltransferase (COMT) gene G↔A (Val 158 Met) single-nucleotide polymorphism (SNP) with BPH in Babylon Province. Materials and Methods: To accomplish this purpose, 146 patients with BPH and 102 apparently healthy controls were subjected to the study. DNA was extracted from whole blood for all samples. Genotyping of COMT gene G↔A (Val 158 Met) SNP was carried out by allele-specific oligonucleotides-polymerase chain reaction. Results: Results indicated that the homozygous genotype (Met158Met) (AA) of COMT gene G↔A (Val 158 Met) SNP was found to be significantly increase the risk of BPH by three folds with respect to those of the wild genotype (Val158Val) (GG) of COMT gene G↔A (Val 158 Met) SNP. The heterozygous genotype (Val158Met) (GA) of COMT gene G↔A (Val 158 Met) SNP was found to be none significantly increase the risk of BPH with respect to those of the wild genotype (Val158Val) (GG) of COMT gene G↔A (Val 158 Met) SNP. The minor allele frequencies (A) of COMT gene G↔A (Val 158 Met) SNP were significantly higher in BPH patients when compared with that of the control group. Conclusions: The COMT gene G↔A (Val 158 Met) SNP is involved in the pathogenesis of BPH.


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