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Year : 2018  |  Volume : 15  |  Issue : 4  |  Page : 286-290

Prevalence of hypothyroidism in type2 diabetic female Kurdish subjects

Department of Internal Medicine, College of Medicine, Hawler Medical University, Erbil, Iraq

Correspondence Address:
Sarheed Jabar Muhammed
Department of Internal Medicine, College of Medicine, Hawler Medical University, Erbil
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/MJBL.MJBL_99_18

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Background: The incidence of thyroid disorders is more prevalent in type1 diabetes compared to type2 diabetes, due to associated autoimmune disorders. Physiological and biochemical interconnection between type1 diabetes mellitus and autoimmune thyroid disease is now stimulating subject of study. Objectives: The objective was to assess the prevalence of thyroid dysfunction among type2 diabetic Kurdish females and to explore the correlation between metabolic syndrome components and autoimmune thyroid abnormality. Materials and Methods: The study included 60 type2 diabetic Kurdish females and 30 sex-and age-matched controls. All patients in the study were exposed to anthropometric characteristics, including HbA1c, lipid profile, serum uric acid, thyroid-stimulating hormone(TSH), free triiodothyronine, free thyroxine, anti-thyroid peroxidase(TPO), and anti-thyroglobulin(anti-Tg). Results: Primary hypothyroidism was found in 24(40%) diabetic patients(5.67±3.35 μIU/mL) versus three(10%) controls (1.76±1.19 μIU/mL) (P<0.001). Anti-TPO was found in 66.7%(367.21±234.53) of diabetic patients versus 10%(31.78±32.14) of controls(P > 0.001). Anti-Tg was found in 60%(499.98±358.14) of diabetic patients versus 0(53.27±36.23) controls(P > 0.001). Asignificant positive relationship was estimated between both TPO antibodies and Tg antibodies and TSH(P=0.05 and P =0.001, respectively) in diabetic patients. Conclusion: Autoimmune thyroid disorder is more prevalent in Kurdish women with type2 diabetes than nondiabetic women, and thus points to a role of autoimmunity in the pathogenesis of type2 diabetes.

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