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Table of Contents
LETTER TO EDITOR
Year : 2020  |  Volume : 17  |  Issue : 3  |  Page : 305-307

Percutaneous biliary drainage in malignant biliary obstruction: Results of initial experience


Shaheed Al-Mihrab Center of Cardiac Surgery and Catheterization, Babil Health Directorate, Al Hilla, Iraq

Date of Submission15-Sep-2018
Date of Acceptance29-May-2020
Date of Web Publication16-Sep-2020

Correspondence Address:
Zaid Hadi Hammoodi
Shaheed Al-Mihrab Center of Cardiac Surgery and Catheterization, Babil Health Directorate, Al Hilla
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/MJBL.MJBL_96_18

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How to cite this article:
Hammoodi ZH. Percutaneous biliary drainage in malignant biliary obstruction: Results of initial experience. Med J Babylon 2020;17:305-7

How to cite this URL:
Hammoodi ZH. Percutaneous biliary drainage in malignant biliary obstruction: Results of initial experience. Med J Babylon [serial online] 2020 [cited 2020 Oct 25];17:305-7. Available from: https://www.medjbabylon.org/text.asp?2020/17/3/305/295148



Dear Editor,

Malignant biliary obstruction is caused mainly by pancreatic tumors, metastatic diseases, cholangiocarcinoma, and carcinoma of gallbladder.[1] Percutaneous transhepatic biliary drainage (PTBD) and endoscopic retrograde cholangiopancreatography (ERCP) are widely used palliative procedures, each with its own merits and lacunae.[2] Percutaneous biliary drainage is one of the several methods of palliating patients with unresectable carcinoma.[3] Improvement in PTBD procedure with advanced in its material consumables, making PTBD equal to ERCP success and complications, with significant reduction in mortality and more survival benefit. PTBD is an image-guided procedure done usually under both fluoroscope and ultrasound (US); its main indications are cholangitis, pruritus, pain alleviation, relief of obstructive jaundice, and in stent placement or transhepatic brachytherapy for local malignant tumor treatment. When stenting is indicated in elderly and frail patients, the endoscopic method should be tried first.[4] Stents were the most effective in achieving long-term palliation; patency was significantly affected by the level of obstruction but not by the type of obstructing tumor.[5] Percutaneously placed self-expandable metallic stents (SEMSs) achieved satisfactory palliation with a low complication rate in a high-risk patient group with advanced malignant biliary obstruction.[6]

From May 2016 to January 2017, 32 patients referred to Shaheed Al-Mihrab Center for Catheterization and Cardiac Surgery, Babylon province, Iraq, for PTBD either when ERCP is not possible (failed trials, contraindications, and previous bypass surgery) or unresectable malignant obstruction, with a mean age of 62.4 years (range 47–77 years).

Under conscious sedation and after review of computed tomography (CT) and magnetic resonance imaging (MRI) studies, best segment puncture was chosen under US guidance with an 18G, 22-cm needle either from the right or left biliary ducts; cholangiography was done using iodine contrast to map the biliary ducts, and then a guidewire is passed into the biliary ducts and negotiated to cross the obstructive lesion using hydrophilic wire of 0.0035” or 0.0014” into the duodenum. A plastic pigtail catheter (8–10 Fr) is placed for internal–external and/or internal–internal drainage; sometimes, a direct metallic stent is placed across the obstruction, again with temporary plastic catheter placement for 3 days. Postoperative analgesia is maintained with follow-up for 6 h for any immediate complications, with same day discharge. Pre procedure, antibiotics metronidazole 500 mg and ceftriaxone 1 g intravenously were given to all patients, with postprocedural oral antibiotics, metronidazole 500 mg and oral ciprofloxacin 750 mg, given for 3 days.

This study was conducted in accordance with the ethical principles that have their origin in the Declaration of Helsinki. It was carried out with patients' verbal and analytical approval before the sample was taken. The study protocol and the subject information and consent form were reviewed and approved by a local ethics committee.


  Results Top


PTBD was done in 32 patients with malignant biliary obstruction (11 female patients and 21 male patients). The causes of obstructive jaundice were pancreatic carcinoma in 13 patients (40.6%), cholangiocarcinoma in 11 patients (34.3%), gallbladder carcinoma in two patients (6.2%), and metastases in six patients (18.7%) [Figure 1].
Figure 1: Distribution of patients according to the cause of biliary obstruction

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Access puncture site from the left biliary ducts in four patients (12.5%), access from the right biliary ducts in 28 patients (87.5%), immediate stenting was done in five patients (15.6%) using 10 mm diameter covered SEMS is placed across the obstructive lesion (covered biliary stent, Cook); in the other twenty patients (62.5%), 8–10 Fr pigtail hydrophilic plastic catheter is placed into the duodenum for internal–internal and internal–external drainage with late stenting done after 1 week. In seven patients (21.9%), crossing of obstructive lesion was failed, and only internal–external biliary catheter was placed. Technical success with catheter placement and drainage was achieved in all patients. No procedure-related mortality occurred. Two patients died after 1 month from advanced disease, three patients (9.3%) died after 3 months, and a total of five patients (15.6%) died after 6 months due to the original advanced malignancy. Early complications in the 1st month in the form of fever, jaundice, and stent block occurred in two patients (6.3%) and late complications (stent occlusion and septicemia) at 6 months occurred in four patients (12.5%) [Table 1].
Table 1: Association between death after 6 months and study variables

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To our knowledge, this is the first study of PTBD and percutaneous stenting efficacy in Iraq, and follow-up in patients with obstructive jaundice caused by unresectable malignant tumors. Biliary endoprostheses inserted percutaneously or endoscopically can provide excellent palliation. Percutaneous biliary drainage may be performed when endoscopic biliary drainage is not possible or unsuccessful or with obstruction at or above the hepatic duct bifurcation.[7] Metallic stents were used for all patients because the costs are calculated for stents and hospital stay for required reinterventions was higher in the plastic stent. Hence, metal stent insertion for palliation of hilar malignancies does not only offer higher success rates and higher patency rates compared to plastic stent insertion, but is also cost-effective because patients require fewer reinterventions.[8]

Self-expandable, metallic stents can be inserted percutaneously through a small transhepatic track but expand to achieve a relatively large internal diameter. In this study, pancreatic carcinoma was the most common cause of malignant obstruction (40.6%), followed by cholangiocarcinoma and ampullary tumor (34.4%), metastases (18.7%), and gallbladder tumors (6.3%). Right biliary access by puncture of segment VI or V ducts was done in 87.5% of patients and left biliary access by puncture of segment III duct in 12.5% of cases; this was done under US guidance after the review of CT and/or MRI.

Right biliary access is preferred in most of our patients because there is less radiation dose to the operator and drain larger amount of liver parenchyma. Left biliary access reserved for patients with mild ascites, right access is not possible or if technically easier, this is similar in most other studies like study by Covey et al.[9] or a study by Teixeira et al.[10] Stent occlusion and jaundice occurred as early as 3 months in two patients, with another two patients also complain from stent occlusion in the following 6 months, i.e., total four stent occlusions at 6 months (16%), it seems from overgrowth of tumor along the stent margins, these results are consistent with a several authors worldwide.[1],[11],[12],[13] Two patients (6.2%) died after 1 month, three patients (9.3%) died after 3 months, and a total of five patients (15.6%) died after 6 months from original advanced malignancy which is observed in a patient with cholangiocarcinoma and pancreatic malignancy.

PTBD for palliation of malignant obstructive jaundice has evolved to a safe and effective technique, and it is equally effective for the treatment of distal and proximal bile obstruction using metallic stents. High technical and clinical success in all major series. Although multiple complications are possible, most can be treated conservatively, and procedure-related mortality is very low in most series. Improvement in patient quality of life and decrease in bilirubin level permitting chemotherapy administration occur in a significant number of patients.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
van Delden OM, Laméris JS. Percutaneous drainage and stenting for palliation of malignant bile duct obstruction. Eur Radiol 2008;18:448-56.  Back to cited text no. 1
    
2.
Chandrashekhara SH, Gamanagatti S, Singh A, Bhatnagar S. Current status of percutaneous transhepatic biliary drainage in palliation of malignant obstructive jaundice: A review. Indian J Palliat Care 2016;22:378-87.  Back to cited text no. 2
[PUBMED]  [Full text]  
3.
Kaufman SL. Percutaneous palliation of unresectable pancreatic cancer. Surg Clin North Am 1995;75:989-99.  Back to cited text no. 3
    
4.
Speer AG, Cotton PB, Russell RC, Mason RR, Hatfield AR, Leung JW, et al. Randomised trial of endoscopic versus percutaneous stent insertion in malignant obstructive jaundice. Lancet 1987;2:57-62.  Back to cited text no. 4
    
5.
Rossi P, Bezzi M, Rossi M, Adam A, Chetty N, Roddie ME, et al. Metallic stents in malignant biliary obstruction: Results of a multicenter European study of 240 patients. J Vasc Interv Radiol 1994;5:279-85.  Back to cited text no. 5
    
6.
Zurstrassen CE, Bitencourt AG, Guimaraes MD, Cavalcante AC, Tyng CJ, Amoedo MK, et al. Percutaneous stent placement for the treatment of malignant biliary obstruction: Nitinol versus elgiloy stents. Radio Bras 2017;50:97-102.  Back to cited text no. 6
    
7.
Ducreux M, Liguory C, Lefebvre JF, Ink O, Choury A, Fritsch J, et al. Management of malignant hilar biliary obstruction by endoscopy. Results and prognostic factors. Dig Dis Sci 1992;37:778-83.  Back to cited text no. 7
    
8.
Wagner HJ, Knyrim K, Vakil N, Klose KJ. Plastic endoprostheses versus metal stents in the palliative treatment of malignant hilar biliary obstruction. A prospective and randomized trial. Endoscopy 1993;25:213-8.  Back to cited text no. 8
    
9.
Covey AM, Brown KT. Percutaneous transhepatic biliary drainage. Tech Vasc Interv Radiol 2008;11:14-20.  Back to cited text no. 9
    
10.
Teixeira MC, Mak MP, Marques DF, Capareli F, Carnevale FC, Moreira AM, et al. Percutaneous transhepatic biliary drainage in patients with advanced solid malignancies: Prognostic factors and clinical outcomes. J Gastrointest Cancer 2013;44:398-403.  Back to cited text no. 10
    
11.
Hong WD, Chen XW, Wu WZ, Zhu QH, Chen XR. Metal versus plastic stents for malignant biliary obstruction: An update meta-analysis. Clin Res Hepatol Gastroenterol 2013;37:496-500.  Back to cited text no. 11
    
12.
Kim HS, Lee DK, Kim HG, Park JJ, Park SH, Kim JH, et al. Features of malignant biliary obstruction affecting the patency of metallic stents: A multicenter study. Gastrointest Endosc 2002;55:359-65.  Back to cited text no. 12
    
13.
Abraham NS, Barkun JS, Barkun AN. Palliation of malignant biliary obstruction: A prospective trial examining impact on quality of life. Gastrointest Endosc 2002;56:835-41.  Back to cited text no. 13
    


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