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ORIGINAL ARTICLE
Year : 2020  |  Volume : 17  |  Issue : 4  |  Page : 353-357

Assessment of renal involvement in an Iraqi cohort of rheumatoid arthritis


1 Department of Internal Medicine, KBMS, Erbil, Iraq
2 Department of Internal Medicine, College of Medicine, HMU, Erbil, Iraq

Correspondence Address:
Bzhar Abdullah Abubaker
Department of Internal Medicine, KBMS, Erbil
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/MJBL.MJBL_29_20

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Background: Rheumatoid arthritis (RA) is an autoimmune chronic systemic inflammatory disease involves synovial joints but may involve extra-articular organ as well. Objectives: to determine the prevalence of indicators of renal involvement in patients with RA with implications of impact of related drugs on the kidney. Materials and Methods: This cross-sectional study was conducted from May 1, 2019, to November 1, 2019, in the Outpatient Rheumatology Clinic of Hawler teaching hospital, Erbil, Iraq. One hundred and seventy-six patients with seropositive RA were enrolled, other 13 were dropped because of missing data. Participant's characteristics and data regarding drug history were collected. Body mass index (BMI), erythrocyte sedimentation rate (ESR), and serum creatinine were measured; renal function was assessed from the estimated glomerular filtration rate (eGFR) using the modification of diet in renal disease formula. Urine examined for proteinuria, microscopic hematuria, and noninfectious leucocyturia. When eGFR <60 ml/min/1.73 m2 regarded as renal impairment, impact of RA medications non-steroidal anti-inflammatory drug, disease-modifying anti-rheumatic drugs, and biological agents on renal function and urine sediments were studied. Results: Out of a total 176 RA patients, 56.8% were females, their mean age 50.4 (±10.4) years, BMI 28.7 (±3.6) kg/m2, with disease duration 8.3(±4.5) years. Renal impairment was detected in 20 (11.4%) participants. Proteinuria, hematuria, and uninfectious leucocyturia were observed in 10.2%, 23.9%, and 25%, respectively. Renal dysfunction was significantly associated with old ages, BMI ≥30, long duration of disease and proteinuria (P = 0.004, 0.002, 0.014, and 0.009, respectively). Renal impairment was not significantly associated with sex, smoking status, ESR level, RA medications, hematuria, and uninfectious leucocyturia (P > 0.5). Conclusions: Renal disorder is common in RA patients. Regular monitoring of renal involvement by using eGFR and urinary dipstick is crucial, especially in the elderly obese RA patients with a long duration of the disease and proteinuria. Early identification of renal disease can facilitate the early intervention and achieve the better management of RA patients.


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