Medical Journal of Babylon

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 17  |  Issue : 3  |  Page : 292--296

Impact of chronic hepatitis B virus infection on bone mineral density


Istabraq A Al-Husseiny1, Maysaa K Al-Malkey1, Maitham A Al-Sammak2, Faheema J Abo-Alhur1 
1 Tropical Biological Research Unit, College of Science, University of Baghdad, Baghdad, Iraq
2 Nebraska Center for Virology, University of Nebraska, Lincoln, USA

Correspondence Address:
Istabraq A Al-Husseiny
Tropical.Biological Research Unit, College of Science, University of Baghdad, Baghdad
Iraq

Background: Chronic hepatitis B virus (HBV) infection is a common health problem that has a worldwide distribution. Apart from the direct effect of the virus on the liver, there are many extrahepatic manifestations among which the probable effect on bone turnover associated with low bone mineral density (BMD). Objectives: This study aimed to determine the association between treated and untreated chronic HBV infection with BMD. Methods: This is a cross-sectional study which included a total of 48 patients with chronic HBV (28 patients treated with tenofovir-disoproxil-fumarate [TDF] antiviral drug and 20 patients have not yet started treatment). Other age- and sex-matched 30 apparently healthy individuals were recruited to represent the healthy controls. BMD was measured using dual-energy X-ray absorptiometry on the anteroposterior lumbar spine (L1–L4 spine) views, from which T-score was calculated. Liver function tests were also evaluated from serum samples. Results: Treated patients showed a lower T-score (−0.48 ± 0.72) than either healthy individuals (1.08 ± 0.84) or untreated patients (0.78 ± 0.51), with highly significant differences. In multivariate regression, only disease duration (adjusted odds ratio [OR] = 9.71, 95% confidence interval [CI] = 4.8–16.68) and TDF treatment (adjusted OR = 6.4, 95% CI = 4.18–97.05) were significantly associated with BMD. Conclusions: Prolonged use of TDF in the treatment of HBV infection can significantly reduce BMD. Moreover, BMD can also be inversely affected in long-standing HBV, regardless of treatment regimen.


How to cite this article:
Al-Husseiny IA, Al-Malkey MK, Al-Sammak MA, Abo-Alhur FJ. Impact of chronic hepatitis B virus infection on bone mineral density.Med J Babylon 2020;17:292-296


How to cite this URL:
Al-Husseiny IA, Al-Malkey MK, Al-Sammak MA, Abo-Alhur FJ. Impact of chronic hepatitis B virus infection on bone mineral density. Med J Babylon [serial online] 2020 [cited 2020 Oct 29 ];17:292-296
Available from: https://www.medjbabylon.org/article.asp?issn=1812-156X;year=2020;volume=17;issue=3;spage=292;epage=296;aulast=Al-Husseiny;type=0